Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Implantation involves an extensive cross talk between the trophoblast cells and the receptive
endometrium through embryonic as well as endometrial‐derived factors that regulate the …

As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

In humans, cell fusion is restricted to only a few cell types under normal conditions. In the
placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant …

The combination of EGF, CHIR99021, A83-01, SB431542, VPA, and Y27632 (EGF/CASVY)
facilitates the derivation of trophoblast stem (TS) cells from human blastocysts and first …

Proper development of the placenta is vital for pregnancy success. The placenta regulates
exchange of nutrients and gases between maternal and fetal blood and produces hormones …

Although the expression of endogenous retroviruses in the placenta of numerous species
was observed a long time ago, their physiological function during gestation was …

Placental dysfunction refers to the insufficiency of placental perfusion and chronic hypoxia
during early pregnancy, which impairs placental function and causes inadequate supply of …

Human endogenous retroviruses (ERVs) represent 8% of the total human genome. Although
the majority of these ancient proviral sequences have only retained non-coding long …