Practical recommendations for using ctDNA in clinical decision making

SA Cohen, MC Liu, A Aleshin - Nature, 2023 - nature.com
The continuous improvement in cancer care over the past decade has led to a gradual
decrease in cancer-related deaths. This is largely attributed to improved treatment and …

Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer

D Kotani, E Oki, Y Nakamura, H Yukami, S Mishima… - Nature medicine, 2023 - nature.com
Despite standard-of-care treatment, more than 30% of patients with resectable colorectal
cancer (CRC) relapse. Circulating tumor DNA (ctDNA) analysis may enable postsurgical risk …

Using cfDNA and ctDNA as oncologic markers: a path to clinical validation

J Dao, PJ Conway, B Subramani… - International journal of …, 2023 - mdpi.com
The detection of circulating tumor DNA (ctDNA) in liquid biopsy samples as an oncological
marker is being used in clinical trials at every step of clinical management. As ctDNA-based …

Advances in novel strategies for isolation, characterization, and analysis of CTCs and ctDNA

V Yaghoubi Naei, P Bordhan… - Therapeutic …, 2023 - journals.sagepub.com
Over the past decade, the detection and analysis of liquid biopsy biomarkers such as
circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have advanced …

Circulating tumor DNA: current challenges for clinical utility

DK Dang, BH Park - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
Cancer cells shed naked DNA molecules into the circulation. This circulating tumor DNA
(ctDNA) has become the predominant analyte for liquid biopsies to understand the …

ctDNA for the Evaluation and Management of EGFR-Mutant Non-Small Cell Lung Cancer

A Desai, TA Vázquez, KM Arce, M Corassa, PC Mack… - Cancers, 2024 - mdpi.com
Simple Summary Lung cancer patients with a specific gene mutation often undergo tissue
biopsies to guide treatment. But what if a simple blood test could do the same? This review …

Early real-world experience monitoring circulating tumor DNA in resected early-stage non–small cell lung cancer

TK Martin, A Dinerman, S Sudhaman, G Budde… - The Journal of Thoracic …, 2024 - Elsevier
Objective The study objective was to evaluate the impact of monitoring circulating tumor
DNA on the detection and management of recurrence in patients with resected early-stage …

[HTML][HTML] Evolving management of breast cancer in the era of predictive biomarkers and precision medicine

MZ Afzal, LT Vahdat - Journal of Personalized Medicine, 2024 - ncbi.nlm.nih.gov
Breast cancer is the most common cancer among women in the world as well as in the
United States. Molecular and histological differentiation have helped clinicians optimize …

BESPOKE IO protocol: a multicentre, prospective observational study evaluating the utility of ctDNA in guiding immunotherapy in patients with advanced solid tumours

PM Kasi, S Chakrabarti, S Sawyer, M Krainock… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Immunotherapy (IO) has transformed the treatment paradigm for a wide variety
of solid tumours. However, assessment of response can be challenging with conventional …

Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers–current evidence and future directions

RCT Lam, D Johnson, G Lam, MLY Li… - Frontiers in …, 2022 - frontiersin.org
Advances in Next Generation Sequencing (NGS) technologies have enabled the accurate
detection and quantification of circulating tumor-derived (ct) DNA in most gastrointestinal …