Understanding cell penetration of cyclic peptides
Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …
Cell-surface interactions on arginine-rich cell-penetrating peptides allow for multiplex modes of internalization
S Futaki, I Nakase - Accounts of chemical research, 2017 - ACS Publications
Conspectus One of the recent hot topics in peptide-related chemical biology research is the
potential of cell-penetrating peptides (CPPs). Owing to their ability to deliver exogenous …
potential of cell-penetrating peptides (CPPs). Owing to their ability to deliver exogenous …
Membrane active peptides and their biophysical characterization
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …
active peptides. These peptides exert their biological activity by interacting with the cell …
[HTML][HTML] Arginine-rich cell-penetrating peptides
Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the
plasma membranes of eukaryotic cells. While successful intracellular delivery of many …
plasma membranes of eukaryotic cells. While successful intracellular delivery of many …
Fundamental molecular mechanism for the cellular uptake of guanidinium-rich molecules
Guanidinium-rich molecules, such as cell-penetrating peptides, efficiently enter living cells in
a non-endocytic energy-independent manner and transport a wide range of cargos …
a non-endocytic energy-independent manner and transport a wide range of cargos …
Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions
A Mishra, GH Lai, NW Schmidt… - Proceedings of the …, 2011 - National Acad Sciences
Cell-penetrating peptides (CPPs), such as the HIV TAT peptide, are able to translocate
across cellular membranes efficiently. A number of mechanisms, from direct entry to various …
across cellular membranes efficiently. A number of mechanisms, from direct entry to various …
Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides
G Lättig-Tünnemann, M Prinz, D Hoffmann… - Nature …, 2011 - nature.com
In addition to endocytosis-mediated cellular uptake, hydrophilic cell-penetrating peptides
are able to traverse biological membranes in a non-endocytic mode termed transduction …
are able to traverse biological membranes in a non-endocytic mode termed transduction …
Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery
From nanopharmaceutics to renewable energy, silver nanoparticles (AgNPs) present
innumerable applications in the contemporary era. However, the associated toxicity to the …
innumerable applications in the contemporary era. However, the associated toxicity to the …
Minimal surfaces in porous media: Pore-scale imaging of multiphase flow in an altered-wettability Bentheimer sandstone
High-resolution x-ray imaging was used in combination with differential pressure
measurements to measure relative permeability and capillary pressure simultaneously …
measurements to measure relative permeability and capillary pressure simultaneously …
Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell-penetrating peptides
Recent molecular-dynamics simulations have suggested that the arginine-rich HIV Tat
peptides translocate by destabilizing and inducing transient pores in phospholipid bilayers …
peptides translocate by destabilizing and inducing transient pores in phospholipid bilayers …