The type 1 insulin-like growth factor receptor (IGF-1R), a transmembrane tyrosine kinase, is
widely expressed across many cell types in foetal and postnatal tissues. Activation of the …

The following brief summary is based on a recent wx review by Rubin and Baserga 1, and
the reader is referred to that review for extended references. A simplified representation of …

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …

In addition to its well-known role in recognition by the proteasome, ubiquitin-conjugation is
also involved in downregulation of membrane receptors, transporters and channels. In most …

The insulin-like growth factor-I receptor (IGF-IR) plays a critical role in cell growth regulation
and transformation. The radiosensitivity of NIH 3T3 fibroblasts overexpressing either wild …

The adapter protein Grb10 belongs to a superfamily of related proteins, including Grb7,-10,
and-14 and Caenorhabditis elegans Mig10. Grb10 is an interacting partner of the insulin-like …

Genomic imprinting is widespread in eutherian mammals. Marsupial mammals also have
genomic imprinting, but in fewer loci. It has long been thought that genomic imprinting is …

The insulin-like growth factor I (IGF-I) receptor (IGF-IR) is known to regulate a variety of
cellular processes including cell proliferation, cell survival, cell differentiation, and cell …

The Grb proteins (growth factor receptor-bound proteins) Grb7, Grb10 and Grb14 constitute
a family of structurally related multidomain adapters with diverse cellular functions. Grb10 …

Grb7 family adaptor molecules consist of Grb7, Grb10 and Grb14, each of which has several
splicing variants. Like other adaptor molecules, Grb7 family proteins function to mediate the …