MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases

X Wang, Y He, B Mackowiak, B Gao - Gut, 2021 - gut.bmj.com
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene
expression by binding to specific mRNA targets and promoting their degradation and/or …

Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of …

JM Banales, V Cardinale, G Carpino… - Nature reviews …, 2016 - research.ed.ac.uk
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of
biliary tract differentiation. CCA is the second most common primary liver tumour and the …

The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics

D Bautista-Sánchez, C Arriaga-Canon… - … Therapy-Nucleic Acids, 2020 - cell.com
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene
expression via base-pairing complementarity. Their role in cancer can be related to tumor …

MicroRNA-21–dependent macrophage-to-fibroblast signaling determines the cardiac response to pressure overload

D Ramanujam, AP Schön, C Beck, P Vaccarello… - Circulation, 2021 - Am Heart Assoc
Background: Cardiac macrophages (cMPs) are increasingly recognized as important
regulators of myocardial homeostasis and disease, yet the role of noncoding RNA in these …

Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population

F Åberg, J Helenius‐Hietala, P Puukka, M Färkkilä… - Hepatology, 2018 - journals.lww.com
Several staging systems for hepatocellular carcinoma (HCC) have been developed. The
Barcelona Clinic Liver Cancer staging system is considered the best in predicting survival …

RNA therapeutics in cardiovascular disease

T Lucas, A Bonauer, S Dimmeler - Circulation research, 2018 - Am Heart Assoc
Noncoding RNAs have been shown to exert important physiological and pathophysiological
functions. Various studies suggest that modulating noncoding RNAs may provide a …

Potential effect of exosomes derived from cancer stem cells and MSCs on progression of DEN‐induced HCC in rats

FA Alzahrani, MA El-Magd… - Stem Cells …, 2018 - Wiley Online Library
Cross talk, mediated by exosomes, between normal stem cells and cancer stem cells
(CSCs) in the tumor microenvironment has been given less attention so far. In addition, no …

AntimiR-21 prevents myocardial dysfunction in a pig model of ischemia/reperfusion injury

R Hinkel, D Ramanujam, V Kaczmarek, A Howe… - Journal of the American …, 2020 - jacc.org
Background miR-21 is a central regulator of cardiac fibrosis, and its inhibition in small-
animal models has been shown to be an effective antifibrotic strategy in various organs …

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

JM Banales, V Cardinale, G Carpino… - Nature Reviews …, 2016 - nature.com
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of
biliary tract differentiation. CCA is the second most common primary liver tumour and the …

[HTML][HTML] Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease

J Jiao, JI Sanchez, OA Saldarriaga, LM Solis… - JHEP Reports, 2023 - Elsevier
Background & Aims The prevalence of non-alcoholic fatty liver disease (NAFLD) and its
severe form, non-alcoholic steatohepatitis (NASH), is increasing. Individuals with NASH …