Evidence of human acute myeloid leukemia stem cells (AML LSCs) was first reported nearly
2 decades ago through the identification of rare subpopulations of engrafting cells in …

Recent major advances in understanding the molecular basis of acute myeloid leukemia
(AML) provide a double-edged sword. Although defining the topology and key features of …

Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …

Biallelic mutations of the CEBPA gene (CEBPA bi) define a distinct entity associated with
favorable prognosis; however, the role of monoallelic mutations (CEBPA sm) is poorly …

The blood system is maintained by a small pool of haematopoietic stem cells (HSCs), which
are required and sufficient for replenishing all human blood cell lineages at millions of cells …

Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML)
have revealed a striking heterogeneity with regard to the presence of acquired gene …

Haematopoietic stem cells (HSCs) are multipotent, but individual HSCs can show restricted
lineage output in vivo. Currently, the molecular mechanisms and physiological role of HSC …

One of the most studied transcription factors in hematopoiesis is the leucine zipper CCAAT-
enhancer binding protein α (C/EBPα), which is mainly involved in cell fate decisions for …

The quiescent (G0) phase of the cell cycle is the reversible phase from which the cells exit
from the cell cycle. Due to the difficulty of defining the G0 phase, quiescent cells have not …

Cell fate decisions during haematopoiesis are governed by lineage‐specific transcription
factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. To gain insight into …