Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease

AR Bourgonje, M Feelisch, KN Faber, A Pasch… - Trends in molecular …, 2020 - cell.com
Inflammatory bowel disease (IBD) is associated with the production of reactive species that
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …

Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies

T Tian, Z Wang, J Zhang - Oxidative medicine and cellular …, 2017 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

Colon‐targeted adhesive hydrogel microsphere for regulation of gut immunity and flora

H Liu, Z Cai, F Wang, L Hong, L Deng… - Advanced …, 2021 - Wiley Online Library
Intestinal immune homeostasis and microbiome structure play a critical role in the
pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment …

The potential roles of natural plant polysaccharides in inflammatory bowel disease: A review

W Yang, P Zhao, X Li, L Guo, W Gao - Carbohydrate Polymers, 2022 - Elsevier
Inflammatory bowel disease (IBD) is a long-term chronic disease, about 20% of IBD patients
deteriorate to colorectal cancer. Currently, there is no radical cure for IBD. Natural plant …

Caffeic acid supplement alleviates colonic inflammation and oxidative stress potentially through improved gut microbiota community in mice

F Wan, R Zhong, M Wang, Y Zhou, Y Chen… - Frontiers in …, 2021 - frontiersin.org
Caffeic acid (CA) is one of the major phenolic acids of coffee with multiple biological
activities. Our previous study found that 500 mg/kg of chlorogenic acid (CGA) had the …

Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip

W Shin, HJ Kim - Proceedings of the National Academy of …, 2018 - National Acad Sciences
The initiation of intestinal inflammation involves complex intercellular cross-talk of
inflammatory cells, including the epithelial and immune cells, and the gut microbiome. This …

Biocatalytic and antioxidant nanostructures for ROS scavenging and biotherapeutics

L Wang, B Zhu, Y Deng, T Li, Q Tian… - Advanced Functional …, 2021 - Wiley Online Library
In human systems, reactive oxygen species (ROS) significantly affect different physiological
activities and play critical roles in diverse living processes. It is widely known that excessive …

Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis

J Kruk, HY Aboul-Enein, A Kładna… - Free radical …, 2019 - Taylor & Francis
The body of evidence from the past three decades demonstrates that oxidative stress can be
involved in several diseases. This study aims to summarise the current state of knowledge …

[HTML][HTML] Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets

AR Bourgonje, D Kloska, A Grochot-Przęczek… - Redox Biology, 2023 - Elsevier
Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are intimately associated with inflammation and overproduction of reactive …

The role of oxidative stress and its counteractive utility in colorectal cancer (CRC)

D Basak, MN Uddin, J Hancock - Cancers, 2020 - mdpi.com
Simple Summary Colorectal cancer (CRC) is very common throughout the world. Despite an
improved outcome with the current treatment regimen, a huge number of patients relapse …