INTRODUCTION Nucleosomes—the primary, repeating unit of chromatin—package and
protect the genome while also transmitting various regulatory signals through, in part …

Heterochromatin is a gene-repressive protein–nucleic acid ultrastructure that is initially
nucleated by DNA sequences. However, following nucleation, heterochromatin can then …

Mechanisms enabling genetically identical cells to differentially regulate gene expression
are complex and central to organismal development and evolution. While gene silencing …

The formation of heterochromatin at HML, HMR, and telomeres in Saccharomyces
cerevisiae involves two main steps: the recruitment of Sir proteins to silencers and their …

Heterochromatic loci can exhibit different transcriptional states in genetically identical cells.
A popular model posits that the inheritance of modified histones is sufficient for inheritance …

Transcriptional silencing in Saccharomyces cerevisiae is a persistent and highly stable form
of gene repression. It involves DNA silencers and repressor proteins that bind nucleosomes …

Physical contacts between distant loci contribute to regulate genome function. However, the
molecular mechanisms responsible for settling and maintaining such interactions remain …

DNA replication in eukaryotic cells initiates from replication origins that bind the Origin
Recognition Complex (ORC). Origin establishment requires well-defined DNA sequence …

Compact chromatin is closely linked with gene silencing in part by sterically masking access
to promoters, inhibiting transcription factor binding and preventing polymerase from …

Heterochromatic domains are complex structures composed of nucleosome arrays that are
bound by silencing factors. This composition raises the possibility that certain configurations …