Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting
up to 1% of the general population. Its prevalence exponentially increases with age and …

Atrial fibrillation (AF) is the most common sustained arrhythmia in humans. The mechanisms
that govern AF initiation and persistence are highly complex, of dynamic nature, and involve …

Key points• Previous studies have shown that atrial electrical properties are altered
(remodelled) by atrial fibrillation (AF) and that the recurrence of AF is high following …

The electrocardiogram (ECG) empowered clinician scientists to measure the electrical
activity of the heart noninvasively to identify arrhythmias and heart disease. Shortly after the …

Introduction Strong evidence shows that exercise is effective to improve fall risk factors
among older people. However, older people's participation and adherence to exercise …

Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT
syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 …

Atrial fibrillation (AF) is the most common arrhythmia. Gain-of-function mutations in KCNQ1,
the pore-forming α-subunit of the slow delayed rectifier K current (I Ks) channel, have been …

Previous studies have linked dysfunctional I to arising from mutations to KCND3-encoded
Kv4. 3 and KCND2-encoded Kv4. 2 to atrial fibrillation. Using computational models, this …

Gain-of-function mutations in KCNJ2-encoded Kir2. 1 channels underlie variant 3 (SQT3) of
the short QT syndrome, which is associated with atrial fibrillation (AF). Using biophysically …

Constrictor agonists set arterial tone through two coupling processes, one tied to
(electromechanical), the other independent (pharmacomechanical) of, membrane potential …