The skin is the outermost organ of the body and is continuously exposed to external
pathogens. Upon inflammation, various immune cells pass through, reside in or are …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Chronic and excessive inflammation in skin and joints causes significant morbidity in
psoriasis patients. As a prevalent T lymphocyte–mediated disorder, psoriasis, as well as the …

Cancer is a collection of diseases with the common feature of uncontrolled cellular growth.
Most tissues in the body can give rise to cancer, some even yield several types, and each …

An effective immune response depends not only on the proper activation, regulation, and
function of immune cells, but also on their distribution and retention in diverse tissue …

This work describes the first cell-based model of tumor-induced angiogenesis. At the
extracellular level, the model describes diffusion, uptake, and decay of tumor-secreted pro …

Although not completely understood, there is clearly a genetic component in the
development of psoriasis. Twin studies show a 67% concordance for monozygotic twins …

Objectives. Infiltration of synovial tissue by neutrophils is crucial in rheumatoid arthritis (RA),
psoriatic arthritis (PsA) and seronegative arthritis (SA). Altered vascular function and …

Psoriasis is a chronic inflammatory skin disease characterized by exaggerated keratinocyte
proliferation. Current paradigm indicates that psoriasis is driven by T cell–mediated immune …

Angiogenesis is important in the pathogenesis of systemic inflammatory rheumatic diseases,
a family of related disorders that includes rheumatoid arthritis and systemic sclerosis …