DNA methylation is a key layer of epigenetic regulation. The deposition of methylation marks
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …

Cell-type-and condition-specific profiles of gene expression require coordination between
protein-coding gene promoters and cis-regulatory sequences called enhancers. Enhancers …

Summary cis-regulatory elements (CREs) encode the genomic blueprints of spatiotemporal
gene expression programs enabling highly specialized cell functions. Using single-cell …

Divergence of gene function is a hallmark of evolution, but assessing functional divergence
over deep time is not trivial. The few alleles available for cross-species studies often fail to …

Gene expression is a complex process that is essential to living organisms. Gene
expression plays the important role of converting information that is encoded in a gene into a …

Butterfly wing patterns derive from a deeply conserved developmental ground plan yet are
diverse and evolve rapidly. It is poorly understood how gene regulatory architectures can …

Thomas Kuhn described the progress of science as comprising occasional paradigm shifts
separated by interludes of 'normal science'. The paradigm that has held sway since the …

Understanding how regulatory mechanisms evolve is critical for understanding the
processes that give rise to novel phenotypes. Snake venom systems represent a valuable …

Background Transposable elements are increasingly recognized as a source of cis-
regulatory variation. Previous studies have revealed that transposons are often bound by …

For well over half of the 150 years since the discovery of the neural crest, the special ability
of these cells to function as a source of species‐specific pattern has been clearly …