[HTML][HTML] The human mitochondrial replication fork in health and disease
S Wanrooij, M Falkenberg - Biochimica et Biophysica Acta (BBA) …, 2010 - Elsevier
Mitochondria are organelles whose main function is to generate power by oxidative
phosphorylation. Some of the essential genes required for this energy production are …
phosphorylation. Some of the essential genes required for this energy production are …
Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA
JLO Pohjoismäki, S Goffart - Bioessays, 2011 - Wiley Online Library
The organisation of mammalian mitochondrial DNA (mtDNA) is more complex than usually
assumed. Despite often being depicted as a simple circle, the topology of mtDNA can vary …
assumed. Despite often being depicted as a simple circle, the topology of mtDNA can vary …
A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA
M Sanchez-Contreras, MT Sweetwyne… - Nucleic Acids …, 2021 - academic.oup.com
Mutations in mitochondrial DNA (mtDNA) cause maternally inherited diseases, while
somatic mutations are linked to common diseases of aging. Although mtDNA mutations …
somatic mutations are linked to common diseases of aging. Although mtDNA mutations …
Comparative mitochondrial genomics of freshwater mussels (Bivalvia: Unionoida) with doubly uniparental inheritance of mtDNA: gender-specific open reading frames …
Doubly uniparental inheritance (DUI) of mitochondrial DNA in marine mussels (Mytiloida),
freshwater mussels (Unionoida), and marine clams (Veneroida) is the only known exception …
freshwater mussels (Unionoida), and marine clams (Veneroida) is the only known exception …
Evolutionary history of inversions in directional mutational pressures in crustacean mitochondrial genomes: implications for evolutionary studies
I Jakovlić, H Zou, XM Zhao, J Zhang, GT Wang… - Molecular Phylogenetics …, 2021 - Elsevier
Inversions of the origin of replication (ORI) in mitochondrial genomes produce asymmetrical
mutational pressures that can cause strong base composition skews. Due to skews often …
mutational pressures that can cause strong base composition skews. Due to skews often …
Unifying view of stem–loop hairpin RNA as origin of current and ancient parasitic and non-parasitic RNAs, including in giant viruses
H Seligmann, D Raoult - Current opinion in microbiology, 2016 - Elsevier
Highlights•Genomic palindromes increase in parasitic Archaea, α-proteobacteria,
Megaviruses.•rRNA and retrovirus hairpins resemble each other.•Hairpin structure clusters …
Megaviruses.•rRNA and retrovirus hairpins resemble each other.•Hairpin structure clusters …
Slow crabs‐fast genomes: Locomotory capacity predicts skew magnitude in crustacean mitogenomes
Base composition skews (G− C/G+ C) of mitochondrial genomes are believed to be primarily
driven by mutational pressure, which is positively correlated with metabolic rate. In marine …
driven by mutational pressure, which is positively correlated with metabolic rate. In marine …
The inversion of the control region in three mitogenomes provides further evidence for an asymmetric model of vertebrate mtDNA replication
Mitochondrial genomes are known to have a strong strand-specific compositional bias that is
more pronounced at fourfold redundant sites of mtDNA protein-coding genes. This …
more pronounced at fourfold redundant sites of mtDNA protein-coding genes. This …
The uroboros theory of life's origin: 22-nucleotide theoretical minimal RNA rings reflect evolution of genetic code and tRNA-rRNA translation machineries
J Demongeot, H Seligmann - Acta Biotheoretica, 2019 - Springer
Theoretical minimal RNA rings attempt to mimick life's primitive RNAs. At most 25 22-
nucleotide-long RNA rings code once for each biotic amino acid, a start and a stop codon …
nucleotide-long RNA rings code once for each biotic amino acid, a start and a stop codon …
[HTML][HTML] Genetic code optimization for cotranslational protein folding: codon directional asymmetry correlates with antiparallel betasheets, tRNA synthetase classes
H Seligmann, G Warthi - Computational and Structural Biotechnology …, 2017 - Elsevier
A new codon property, codon directional asymmetry in nucleotide content (CDA), reveals a
biologically meaningful genetic code dimension: palindromic codons (first and last …
biologically meaningful genetic code dimension: palindromic codons (first and last …