The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Nuclear lamins are intermediate filament-type proteins that are the major building blocks of
the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear …

Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of
heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome …

Eukaryotic chromosomes contain compartments of various functions, which are marked by
and enriched with specific histone modifications. However, the molecular mechanisms by …

Eukaryotic cells store their chromosomes in a single nucleus. This is important to maintain
genomic integrity, as chromosomes packaged into separate nuclei (micronuclei) are prone …

Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease
caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major …

The mechanisms of localization and retention of membrane proteins in the inner nuclear
membrane and the fate of this membrane system during mitosis were studied in living cells …

It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …