Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

Many sensory systems in cells and organisms share a recurring property called fold-change
detection (FCD). FCD describes a system whose dynamics–including amplitude and …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

The identification of cell borders ('segmentation') in microscopy images constitutes a
bottleneck for large-scale experiments. For the model organism Saccharomyces cerevisiae …

The ability to independently control the expression of different genes is important for
quantitative biology. Using budding yeast, we characterize GAL1pr, GALL, MET3pr, CUP1pr …

Complex systems are characterized by multiple spatial and temporal scales. A natural
framework to capture their multiscale nature is that of multilayer networks, where different …

Dehydrating stresses trigger the accumulation of abscisic acid (ABA), a key plant stress-
signaling hormone that activates Snf1-Related Kinases (SnRK2s) to mount adaptive …

All cells employ signal transduction pathways to respond to physiologically relevant
extracellular cytokines, stressors, nutrient levels, hormones, morphogens, and other stimuli …

The cell cycle is the process by which eukaryotic cells replicate. Yeast cells cycle
asynchronously with each cell in the population budding at a different time. Although there …

The proto-oncogenic epidermal growth factor (EGF) receptor (EGFR) is a tyrosine kinase
whose sensitivity and response to growth factor signals that vary over time and space …