Precision medicine has greatly aided in improving health outcomes using earlier diagnosis
and better prognosis for chronic diseases. It makes use of clinical data associated with the …

The integration of whole genome sequencing (WGS) into all aspects of modern medicine
represents the next step in the evolution of healthcare. Using this technology, scientists and …

Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …

Cholangiocarcinomas (CCA) are a heterogeneous group of tumors that are classified as
intrahepatic, perihilar, or distal according to the anatomic location within the biliary tract …

Tumor type guides clinical treatment decisions in cancer, but histology-based diagnosis
remains challenging. Genomic alterations are highly diagnostic of tumor type, and tumor …

It is increasingly clear that an extraordinarily diverse range of clinically important conditions—
including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions …

Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic
diagnosis of rare and unknown diseases and for identification of actionable cancer drivers …

Mechanistically, chimeric genes result from DNA rearrangements and include parts of
preexisting normal genes combined at the genomic junction site. Some rearranged genes …

The use of next-generation sequencing (NGS) techniques for variant detection has become
increasingly important in clinical research and in clinical practice in oncology. Many cancer …

Aims: This study aimed to identify the correlation and molecular mechanism between TBC1
domain family member 14 (TBC1D14) and lymph node metastasis (LNM) in head and neck …