The Diels–Alder reaction: a powerful tool for the design of drug delivery systems and biomaterials

M Gregoritza, FP Brandl - European journal of pharmaceutics and …, 2015 - Elsevier
Click reactions have the potential to greatly facilitate the development of drug delivery
systems and biomaterials. These reactions proceed under mild conditions, give high yields …

“Clicking” on/with polymers: a rapidly expanding field for the straightforward preparation of novel macromolecular architectures

K Kempe, A Krieg, CR Becer… - Chemical Society Reviews, 2012 - pubs.rsc.org
The combination of controlled polymerization techniques and “click” reactions form an
efficient platform for the preparation of polymers in various architectures. In this critical …

Diels–Alder cycloaddition‐cycloreversion: a powerful combo in materials design

A Sanyal - Macromolecular Chemistry and Physics, 2010 - Wiley Online Library
Reactive polymers are increasingly becoming materials of wide interest because they offer
solutions to challenges in biomolecular immobilization, drug‐delivery and enzyme …

Double click reaction strategies for polymer conjugation and post-functionalization of polymers

H Durmaz, A Sanyal, G Hizal, U Tunca - Polymer Chemistry, 2012 - pubs.rsc.org
Double click reaction strategies, which are a combination of different type of click reactions,
allow the preparation of polymers with various topologies and the post-functionalization of …

Discrete macromolecular constructs via the Diels–Alder “Click” reaction

G Hizal, U Tunca, A Sanyal - Journal of Polymer Science Part A …, 2011 - Wiley Online Library
Functional polymeric materials with desired properties can be designed by precise control of
macromolecular architectures. Over the recent years, click reactions have enabled efficient …

Orthogonal multiple click reactions in synthetic polymer chemistry

U Tunca - Journal of Polymer Science Part A: Polymer …, 2014 - Wiley Online Library
This review highlights the concept of multiple click reaction strategy which is utilized for
design and synthesis of well‐defined complex macromolecular structures as well as …

Design of cross‐linked semicrystalline poly (ε‐caprolactone)‐based networks with one‐way and two‐way shape‐memory properties through Diels–Alder reactions

JM Raquez, S Vanderstappen, F Meyer… - … A European Journal, 2011 - Wiley Online Library
Cross‐linked poly (ε‐caprolactone)(PCL)‐based polyesterurethane (PUR) systems have
been synthesized through Diels–Alder reactions by reactive extrusion. The Diels–Alder and …

Synthesis and functionalization of thiol-reactive biodegradable polymers

S Onbulak, S Tempelaar, RJ Pounder, O Gok… - …, 2012 - ACS Publications
In recent years, reactive degradable polymers have gained increased attention due to their
widespread application in biomedical and materials sciences. Recent progress in efficient …

Multi-functional nanogels as theranostic platforms: exploiting reversible and nonreversible linkages for targeting, imaging, and drug delivery

L Chambre, A Degirmenci, R Sanyal… - Bioconjugate …, 2018 - ACS Publications
Nanogels that are amenable to facile multi-functionalization with imaging, therapeutic, and
targeting agents are attractive theranostic platforms for addressing challenges in …

Triple click reaction strategy for macromolecular diversity

U Tunca - Macromolecular rapid communications, 2013 - Wiley Online Library
Abstract This Feature Article focuses on the rapidly emerging concept of the “triple click
reactions” towards the design and synthesis of macromolecules with well‐defined topology …