Recent studies have revealed extensive genetic and non-genetic variation across different
geographical regions of a tumor or throughout different stages of tumor progression, which is …

Ras proteins are critical nodes in cellular signaling that integrate inputs from activated cell
surface receptors and other stimuli to modulate cell fate through a complex network of …

Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its
genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing …

The genetic heterogeneity of cancer influences the trajectory of tumor progression and may
underlie clinical variation in therapy response. To model such heterogeneity, we produced …

Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a
common event in childhood acute lymphoblastic leukemia and is caused by point mutation …

Drug screening is often limited to cell-free assays involving purified enzymes, but it is
arguably best applied against systems that represent disease states or complex …

Progress in understanding the molecular pathogenesis of human myeloproliferative
disorders (MPDs) has led to guidelines incorporating genetic assays with histopathology …

The p53 tumor suppressor limits proliferation in response to cellular stress through several
mechanisms. Here, we test whether the recently described ability of p53 to limit stem cell self …

Hematopoietic stem cells (HSCs) sustain hematopoiesis throughout life. HSCs exit
dormancy to restore hemostasis in response to stressful events, such as acute blood loss …

The family of Ras-like GTPases consists of over 150 different members, regulated by an
even larger number of guanine exchange factors (GEFs) and GTPase-activating proteins …