Acute respiratory distress syndrome (ARDS) is difficult to treat and is associated with a high
mortality rate. The most severe form of coronavirus disease 2019 (COVID-19) also leads to …

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …

Sepsis remains a leading cause of death worldwide, despite advances in critical care, and
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …

It has been known for many years that neutrophils and platelets participate in the
pathogenesis of severe sepsis, but the inter-relationship between these players is …

As a cornerstone of the innate immune response, neutrophils are the archetypical
phagocytic cell; they actively seek out, ingest, and destroy pathogenic microorganisms. To …

Reactive oxygen species (ROS) are considered to be chemically reactive with and
damaging to biomolecules including DNA, protein, and lipid, and excessive exposure to …

Since the adult respiratory distress syndrome was first described substantial progress has
been made in understanding the pathogenesis of this complex syndrome. This review …

The successful resolution of inflammation is dependent upon the coordinated transition from
the initial recruitment of neutrophils to a more sustained population of mononuclear cells. IL …

Neutrophil migration is a coordinated process that is altered at multiple stages during sepsis.
In combination with impaired neutrophil function, these alterations culminate in defective …

Mycobacterium tuberculosis remains a major public health burden. It is generally thought
that while B cell-and antibody-mediated immunity plays an important role in host defense …