Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology
Y Benatzy, MA Palmer, B Brüne - Frontiers in Pharmacology, 2022 - frontiersin.org
As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …
Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer
A Aliabadi, E Khanniri, M Mahboubi-Rabbani… - European journal of …, 2023 - Elsevier
Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
Pharmacological potential of Jussiaea repens L. against CuSO4 and bacterial lipopolysaccharide O55: B5 induced inflammation using in-vivo zebrafish models
C Rajiv, HS Devi, AK Devi, K Tamreihao… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance The Northeastern state of India is known for its
remarkable biodiversity and untapped medicinal resources. Jussiaea repens L., commonly …
remarkable biodiversity and untapped medicinal resources. Jussiaea repens L., commonly …
[HTML][HTML] Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes)
L Dong, H Wang, K Chen, Y Li - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Hydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonate acid (AA) oxidized
by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and …
by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and …
[HTML][HTML] The Phytochemical Profile of the Petroleum Ether Extract of Purslane Leaves and Its Anticancer Effect on 4-(Methylnitrosamino)-1-(3-pyridyl)-1-buta-4 None …
AS Abd Elkarim, SH Mohamed, NA Ali… - International Journal of …, 2024 - mdpi.com
Lung cancer is a prevalent and very aggressive sickness that will likely claim 1.8 million
lives by 2022, with an estimated 2.2 million additional cases expected worldwide. The goal …
lives by 2022, with an estimated 2.2 million additional cases expected worldwide. The goal …
Pathological and pharmacological functions of the metabolites of polyunsaturated fatty acids mediated by cyclooxygenases, lipoxygenases, and cytochrome P450s in …
YW Meng, JY Liu - Pharmacology & Therapeutics, 2024 - Elsevier
Oxylipins have garnered increasing attention because they were consistently shown to play
pathological and/or pharmacological roles in the development of multiple cancers. Oxylipins …
pathological and/or pharmacological roles in the development of multiple cancers. Oxylipins …
Investigating the Catalytic Site of Human 15‐Lipoxygenase‐1 via Marine Natural Products
N Spacho, M Casertano, C Imperatore… - … A European Journal, 2024 - Wiley Online Library
Abstract Human 15‐lipoxygenase‐1 (15‐LOX‐1) is a key enzyme that possesses an
important role in (neuro) inflammatory diseases. The pocket of the enzyme plays the role of a …
important role in (neuro) inflammatory diseases. The pocket of the enzyme plays the role of a …
[HTML][HTML] Quantitative and qualitative determination of carotenoids and polyphenolics compounds in selected cultivars of Prunus persica L. and their ability to in vitro …
The present study aimed to evaluate the content of polyphenols and carotenoids as well as
the health-promoting properties (antioxidant, antidiabetic, antiobesity, antiaging, and anti …
the health-promoting properties (antioxidant, antidiabetic, antiobesity, antiaging, and anti …
Inflammation Factors and Genistein Supplementation in Cancer—Preliminary Research
K Banyś, M Jelińska, M Wrzosek… - Current Issues in …, 2024 - mdpi.com
The purpose of this study was to evaluate the effect of genistein in nano, micro, and macro
forms on the intensity of the DMBA-induced tumor process in rats and to understand the …
forms on the intensity of the DMBA-induced tumor process in rats and to understand the …
Crafting Molecular Tools for 15‐Lipoxygenase‐1 in a Single Step
A Louka, N Spacho, D Korovesis… - Angewandte Chemie …, 2024 - Wiley Online Library
Small molecule modulators are powerful tools for selectively probing and manipulating
proteins in native biological systems. However, the development of versatile modulators that …
proteins in native biological systems. However, the development of versatile modulators that …