Aluminum-containing adjuvants have been used for over 90 years to enhance the immune
response to vaccines. Recent work has significantly advanced our understanding of the …

Instability of vaccines often emerges as a key challenge during clinical development (lab to
clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious …

The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

Aluminum-containing adjuvants are widely used in preventive vaccines against infectious
diseases and in preparations for allergy immunotherapy. The mechanism by which they …

Vaccine adjuvants interact with the immune system, to increase the potency of vaccine
antigens. Many of the adjuvants currently available were developed with little understanding …

The development of vaccines containing adjuvants has the potential to enhance antibody
and cellular immune responses, broaden protective immunity against heterogeneous …

Forced degradation studies are typically conducted during the early development phase of
vaccine candidates to obtain information on potential degradation pathways, support …

Forced degradation studies are carried out at a more severe condition than accelerated
conditions. Stress studies for vaccines are carried out in the early stage of development. By …

Aluminum based adjuvants are widely used in commercial vaccines, since they are known
to be safe and effective with a variety of antigens. The effect of antigen adsorption onto …

Microplate-based formulation screening is a powerful approach to identify stabilizing
excipients for therapeutic proteins while reducing material requirements. However, this …