Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key
role. An effective therapy for pain depends on the intensity and type of pain, the patients' …

Nitric oxide (NO) is involved in many physiological processes and several lines of evidence
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …

Introduction 3. Discovery of NO 3.1. Nitric oxide and the Nobel prize 3.2. NO generation and
nitric oxide synthase 3.2. 1. eNOS 3.2. 2. iNOS 3.2. 3. nNOS 3.3. Nitrovasodilators 4. NO …

PAIN is “an unpleasant sensory and emotional experience associated with actual or
potential tissue damage, or described in terms of such damage.” 1 In settings where pain is …

Chronic pain remains unsatisfactorily treated, and few novel painkillers have reached the
market in the past century. Increasing the levels of the main endogenous opioid peptides …

The mitochondrial aldehyde dehydrogenase (ALDH2, mtALDH) was recently found to
catalyze the reduction of nitroglycerin (glyceryl trinitrate [GTN]) to generate nitrite and 1, 2 …

Objective Raynaud's phenomenon (RP) affects 3–9% of the general population and> 90% of
patients with systemic sclerosis. Nitrates are often prescribed for the treatment of RP, but …

Organic nitrates such as nitroglycerin (NTG) have been used as potent vasodilators in
medicine for more than a century, but their biochemical mechanisms of action, particularly in …

Nitric oxide (NO) plays pivotal roles in controlling physiological functions, participates in
pathophysiological intervention, and is involved in mechanisms underlying beneficial or …