The vascular endothelial growth factor (VEGF) family, the regulator of blood and lymphatic
vessels, is mostly investigated in the tumor and ophthalmic field. However, the functions it …

The heart hypertrophies in response to developmental signals as well as increased
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …

Vascular endothelial growth factors and their endothelial tyrosine kinase receptors are
central regulators of vasculogenesis, angiogenesis and lymphangiogenesis. VEGF …

The vascular endothelial growth factors (VEGFs) are major angiogenic regulators and are
involved in several aspects of endothelial cell physiology. However, the detailed role of …

Cardiovascular diseases remain a large global health problem. Although several
conventional small-molecule treatments are available for common cardiovascular problems …

Blood vessels form an important interface between the environment and the organism by
carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is …

Chronic cardiovascular diseases are significant health problems. Although current treatment
strategies have tremendously improved disease management, up to 30% of these patients …

Effective myocardial function depends primarily on oxidative energy production. In humans,
at a heart rate of 60 to 70 beats per minute, the oxygen consumption normalized per gram of …

The prevalence of type 2 diabetes is rapidly increasing, with severe socioeconomic impacts,.
Excess lipid deposition in peripheral tissues impairs insulin sensitivity and glucose uptake …

Heart failure is a devastating condition, the progression of which culminates in a mismatch of
oxygen supply and demand, with limited options for treatment. Heart failure has several …