Deubiquitinases: From mechanisms to their inhibition by small molecules

SM Lange, LA Armstrong, Y Kulathu - Molecular cell, 2022 - cell.com
Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …

Breaking the chains: deubiquitylating enzyme specificity begets function

MJ Clague, S Urbé, D Komander - Nature reviews Molecular cell …, 2019 - nature.com
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Deubiquitylases from genes to organism

MJ Clague, I Barsukov, JM Coulson… - Physiological …, 2013 - journals.physiology.org
Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …

Molecular architecture of polycomb repressive complexes

EC Chittock, S Latwiel, TCR Miller… - Biochemical Society …, 2017 - portlandpress.com
The polycomb group (PcG) proteins are a large and diverse family that epigenetically
repress the transcription of key developmental genes. They form three broad groups of …

[HTML][HTML] A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1

NT Hertz, A Berthet, ML Sos, KS Thorn, AL Burlingame… - Cell, 2013 - cell.com
Mitochondria have long been implicated in the pathogenesis of Parkinson's disease (PD).
Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with …

[HTML][HTML] Regulation of proteolysis by human deubiquitinating enzymes

ZM Eletr, KD Wilkinson - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
The post-translational attachment of one or several ubiquitin molecules to a protein
generates a variety of targeting signals that are used in many different ways in the cell …

Structural basis for specific inhibition of the deubiquitinase UCHL1

C Grethe, M Schmidt, GM Kipka, R O'Dea… - Nature …, 2022 - nature.com
Ubiquitination regulates protein homeostasis and is tightly controlled by deubiquitinases
(DUBs). Loss of the DUB UCHL1 leads to neurodegeneration, and its dysregulation …

Meddling with fate: the proteasomal deubiquitinating enzymes

SAH de Poot, G Tian, D Finley - Journal of molecular biology, 2017 - Elsevier
Abstract Three deubiquitinating enzymes—Rpn11, Usp14, and Uch37—are associated with
the proteasome regulatory particle. These enzymes allow proteasomes to remove ubiquitin …

Substrate specificity of the ubiquitin and Ubl proteases

JA Ronau, JF Beckmann, M Hochstrasser - Cell research, 2016 - nature.com
Conjugation and deconjugation of ubiquitin and ubiquitin-like proteins (Ubls) to cellular
proteins are highly regulated processes integral to cellular homeostasis. Most often, the C …

Development and application of ubiquitin-based chemical probes

X Sui, Y Wang, YX Du, LJ Liang, Q Zheng, YM Li… - Chemical …, 2020 - pubs.rsc.org
Protein ubiquitination regulates almost every process in eukaryotic cells. The study of the
many enzymes involved in the ubiquitination system and the development of ubiquitination …