Molecular mechanisms underlying vertebrate adaptive evolution: a systematic review

F Martínez Sosa, M Pilot - Genes, 2023 - mdpi.com
Adaptive evolution is a process in which variation that confers an evolutionary advantage in
a specific environmental context arises and is propagated through a population. When …

Molecular characterization of vancomycin‐resistant Staphylococcus aureus isolated from bovine milk

I Muzammil, M Ijaz, MH Saleem… - Zoonoses and Public …, 2023 - Wiley Online Library
Vancomycin‐resistant Staphylococcus aureus (VRSA) is a zoonotic life‐threatening
pathogen. Vancomycin exhibits anti‐bacterial activity by inhibiting peptidoglycan synthesis …

Positive selection drives the adaptive evolution of mitochondrial antiviral signaling (MAVS) proteins-mediating innate immunity in mammals

HI Ahmad, G Afzal, MN Iqbal, MA Iqbal… - Frontiers in Veterinary …, 2022 - frontiersin.org
The regulated production of filamentous protein complexes is essential in many biological
processes and provides a new paradigm in signal transmission. The mitochondrial antiviral …

Structural and evolutionary adaptations of Nei‐like DNA glycosylases proteins involved in base excision repair of oxidative DNA damage in vertebrates

HI Ahmad, G Afzal, S Sadia, G Haider… - Oxidative medicine …, 2022 - Wiley Online Library
Oxidative stress is a type of stress that damages DNA and can occur from both endogenous
and exogenous sources. Damage to DNA caused by oxidative stress can result in base …

[HTML][HTML] In silico structural, functional, and phylogenetic analysis of cytochrome (CYPD) protein family

HI Ahmad, G Afzal, A Jamal, S Kiran… - BioMed Research …, 2021 - pmc.ncbi.nlm.nih.gov
Cytochrome (CYP) enzymes catalyze the metabolic reactions of endogenous and
exogenous compounds. The superfamily of enzymes is found across many organisms …

[Retracted] Computational Insights into the Structural and Functional Impacts of nsSNPs of Bone Morphogenetic Proteins

HI Ahmad, N Ijaz, G Afzal, AR Asif… - BioMed Research …, 2022 - Wiley Online Library
BMPs (bone morphogenetic proteins) are multipurpose (transforming growth factor) TGF‐
superfamily released cytokines. These glycoproteins, acting as disulfide‐linked homo‐or …

Adaptive evolution of peptidoglycan recognition protein family regulates the innate signaling against microbial pathogens in vertebrates

HI Ahmad, AR Asif, MJ Ahmad, F Jabbir, M Adnan… - Microbial …, 2020 - Elsevier
The innate immune system is the first line of defense in vertebrates against microbial
pathogens. This defense system depends on the peptidoglycan pathogen recognition of …

[Retracted] Molecular Evolution of the Activating Transcription Factors Shapes the Adaptive Cellular Responses to Oxidative Stress

HI Ahmad, A Iqbal, N Ijaz, MI Ullah… - Oxidative Medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) play an essential part in physiology of individual cell. ROS
can cause damage to various biomolecules, including DNA. The systems that have …

In Silico Analysis: Genome-Wide Identification, Characterization and Evolutionary Adaptations of Bone Morphogenetic Protein (BMP) Gene Family in Homo sapiens

Z Riaz, M Hussain, S Parveen, M Sultana… - Molecular …, 2024 - Springer
We systematically analyzed BMP gene family in H. sapiens to elucidate genetic structure,
phylogenetic relationships, adaptive evolution and tissue-specific expression pattern. Total …

[Retracted] In Silico Structural and Functional Analyses of NLRP3 Inflammasomes to Provide Insights for Treating Neurodegenerative Diseases

BK Ghazi, MH Bangash, AA Razzaq… - BioMed Research …, 2023 - Wiley Online Library
Inflammasomes are cytoplasmic intracellular multiprotein complexes that control the innate
immune system's activation of inflammation in response to derived chemicals. Recent …