ZIP transporters‐regulated Zn2+ homeostasis: A novel determinant of human diseases

H Liu, L Li, R Lu - Journal of Cellular Physiology, 2024 - Wiley Online Library
As an essential trace element for organisms, zinc participates in various physiological
processes, such as RNA transcription, DNA replication, cell proliferation, and cell …

Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection

M Gong, C Peng, C Yang, Z Wang, H Qian, X Hu… - Plos …, 2024 - journals.plos.org
The Ebola virus (EBOV) has emerged as a significant global health concern, notably during
the 2013–2016 outbreak in West Africa. Despite the clinical approval of two EBOV antibody …

Targeting altered glycosylation in secreted tumor glycoproteins for broad cancer detection

MR Kudelka, W Gu, Y Matsumoto, T Ju… - …, 2023 - academic.oup.com
There is an urgent need to develop new tumor biomarkers for early cancer detection, but the
variability of tumor-derived antigens has been a limitation. Here we demonstrate a novel anti …

[HTML][HTML] Unraveling the role of C1GALT1 in abnormal glycosylation and colorectal cancer progression

H Tian, JL Yu, X Chu, Q Guan, J Liu, Y Liu - Frontiers in Oncology, 2024 - ncbi.nlm.nih.gov
C1GALT1 plays a pivotal role in colorectal cancer (CRC) development and progression
through its involvement in various molecular mechanisms. This enzyme is central to the O …

Metabolic mapping of the human solute carrier superfamily

T Wiedmer, ST Teoh, E Christodoulaki, G Wolf, C Tian… - BioRxiv, 2024 - biorxiv.org
Solute carrier (SLC) transporters govern most of the chemical exchange across cellular
membranes and are integral to metabolic regulation, which in turn is linked to cellular …

Long-term DEHP/MEHP exposure promotes colorectal cancer stemness associated with glycosylation alterations

PC Shih, HP Chen, CC Hsu, CH Lin, CY Ko… - Environmental …, 2023 - Elsevier
Plasticizers are considered as environmental pollution released from medical devices and
increased potential oncogenic risks in clinical therapy. Our previous studies have shown that …

ZNT5-6 and ZNT7 play an integral role in protein N-glycosylation by supplying Zn2+ to Golgi α-mannosidase II

H Yuasa, N Morino, T Wagatsuma, M Munekane… - Journal of Biological …, 2024 - ASBMB
The stepwise addition of monosaccharides to N-glycans attached to client proteins to
generate a repertoire of mature proteins involves a concerted action of many glycosidases …

The membrane androgen receptor ZIP9 (SCL39A9) maintains ovarian homeostasis by mediating post-ovulatory follicle breakdown in zebrafish

A Converse, H Genuise, TL Bennett, RM Butler… - General and …, 2023 - Elsevier
ZIP9 was recently characterized as a membrane androgen receptor in Atlantic croaker
granulosa/theca (G/T) cells where it mediates androgen-induced apoptosis in vitro, but the …

SLC10A7 regulates O-GalNAc glycosylation and Ca2+ homeostasis in the secretory pathway: insights into SLC10A7-CDG

Z Durin, A Layotte, W Morelle, M Houdou… - Cellular and Molecular …, 2025 - Springer
Glycans are known to be fundamental for many cellular and physiological functions.
Congenital disorders of glycosylation (CDG) currently encompassing over 160 subtypes, are …

[HTML][HTML] C1GALT1 induces the carcinogenesis of thyroid cancer through regulation by miR-141-3p and GLUT1

L Huang, Z Li, Z Xu, R Yu, C Ding, T Sun, L Kong, Z Xia - Heliyon, 2024 - cell.com
Abstract Core 1 β 1, 3-galactosyltransferase 1 (C1GALT1) acts as an important
glycosyltransferase in the occurrence and development of tumor glycosylation. However, the …