Neutralization of virus infectivity by antibodies: old problems in new perspectives
PJ Klasse - Advances in biology, 2014 - Wiley Online Library
Neutralizing antibodies (NAbs) can be both sufficient and necessary for protection against
viral infections, although they sometimes act in concert with cellular immunity. Successful …
viral infections, although they sometimes act in concert with cellular immunity. Successful …
Molecular determinants of the ratio of inert to infectious virus particles
PJ Klasse - Progress in molecular biology and translational …, 2015 - Elsevier
The ratio of virus particles to infectious units is a classic measurement in virology and ranges
widely from several million to below 10 for different viruses. Much evidence suggests a …
widely from several million to below 10 for different viruses. Much evidence suggests a …
Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
Background The trimeric envelope glycoproteins (Env) on the surface of HIV-1 virions are
the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet …
the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet …
Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry
OF Brandenberg, C Magnus, P Rusert… - PLoS …, 2015 - journals.plos.org
HIV-1 enters target cells by virtue of envelope glycoprotein trimers that are incorporated at
low density in the viral membrane. How many trimers are required to interact with target cell …
low density in the viral membrane. How many trimers are required to interact with target cell …
Dense array of spikes on HIV-1 virion particles
ABSTRACT HIV-1 is rare among viruses for having a low number of envelope glycoprotein
(Env) spikes per virion, ie,∼ 7 to 14. This exceptional feature has been associated with …
(Env) spikes per virion, ie,∼ 7 to 14. This exceptional feature has been associated with …
Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies
P Rusert, A Krarup, C Magnus… - Journal of Experimental …, 2011 - rupress.org
The HIV-1 envelope trimer adopts a quaternary conformation that effectively shields
neutralization-sensitive domains and thus represents a major obstacle for natural and …
neutralization-sensitive domains and thus represents a major obstacle for natural and …
The HIV-1 entry process: a stoichiometric view
HIV-1 infection starts with fusion of the viral and the host cell membranes, a process
mediated by the HIV-1 envelope glycoprotein trimer. The number of trimers required to …
mediated by the HIV-1 envelope glycoprotein trimer. The number of trimers required to …
Transient antibody-mucin interactions produce a dynamic molecular shield against viral invasion
Given the difficulty in finding a cure for HIV/AIDS, a promising prevention strategy to reduce
HIV transmission is to directly block infection at the portal of entry. The recent Thai RV144 …
HIV transmission is to directly block infection at the portal of entry. The recent Thai RV144 …
Membrane interference against HIV-1 by intrinsic antiviral factors: the case of IFITMs
F Marziali, A Cimarelli - Cells, 2021 - mdpi.com
HIV-1 is a complex retrovirus that is adapted to replicate in cells of the immune system. To
do so, HIV-1, like other viruses, developed strategies to use several cellular processes to its …
do so, HIV-1, like other viruses, developed strategies to use several cellular processes to its …
IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters
Human interferon-induced transmembrane (IFITM) proteins inhibit the fusion of a broad
spectrum of enveloped viruses, both when expressed in target cells and when present in …
spectrum of enveloped viruses, both when expressed in target cells and when present in …