The majority of exchanges of oxygen and nutrients are performed around vessels smaller
than 100 μm, allowing cells to thrive everywhere in the body. Pathologies such as cancer …

Because it drives the compromise between resolution and penetration, the diffraction limit
has long represented an unreachable summit to conquer in ultrasound imaging. Within a …

Angiogenesis has been known as a hallmark of solid tumor cancers for decades, yet
ultrasound has been limited in its ability to detect the microvascular changes associated with …

Microbubble ultrasound contrast agents (UCAs) were recently approved by the Food and
Drug administration for non-cardiac imaging. The physical principles of UCAs, methods of …

The development of microbubble contrast agents has broadened the scope of medical
ultrasound imaging. Along with dedicated imaging techniques, these agents provide …

Aging-related cognitive decline is an emerging health crisis; however, no established
unifying mechanism has been identified for the cognitive impairments seen in an aging …

A major limitation of current humanized mouse models is that they primarily enable the
analysis of human-specific pathogens that infect hematopoietic cells. However, most human …

Rationale: Structure and function of the microvasculature provides critical information about
disease state, can be used to identify local regions of pathology, and has been shown to be …

The structure of microvasculature cannot be resolved using conventional ultrasound (US)
imaging due to the fundamental diffraction limit at clinical US frequencies. It is possible to …

Background Estimation of glomerular function is necessary to diagnose kidney diseases.
However, the study of glomeruli in the clinic is currently done indirectly through urine and …