Insight into de-regulation of amino acid feedback inhibition: a focus on structure analysis method
Regulation of amino acid's biosynthetic pathway is of significant importance to maintain
homeostasis and cell functions. Amino acids regulate their biosynthetic pathway by end …
homeostasis and cell functions. Amino acids regulate their biosynthetic pathway by end …
[HTML][HTML] Engineering precursor supply for the high-level production of ergothioneine in Saccharomyces cerevisiae
Ergothioneine (ERG) is an unusual sulfur-containing amino acid. It is a potent antioxidant,
which shows great potential for ameliorating neurodegenerative and cardiovascular …
which shows great potential for ameliorating neurodegenerative and cardiovascular …
Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase
BJ Read, AF Cadzow, MS Alphey, JBO Mitchell… - Biochemistry, 2023 - ACS Publications
The first step of histidine biosynthesis in Acinetobacter baumannii, the condensation of ATP
and 5-phospho-α-d-ribosyl-1-pyrophosphate to produce N 1-(5-phospho-β-d-ribosyl)-ATP …
and 5-phospho-α-d-ribosyl-1-pyrophosphate to produce N 1-(5-phospho-β-d-ribosyl)-ATP …
Allosteric activation unveils protein-mass modulation of ATP phosphoribosyltransferase product release
Heavy-isotope substitution into enzymes slows down bond vibrations and may alter
transition-state barrier crossing probability if this is coupled to fast protein motions. ATP …
transition-state barrier crossing probability if this is coupled to fast protein motions. ATP …
Uncoupling conformational states from activity in an allosteric enzyme
JP Pisco, C De Chiara, KJ Pacholarz… - Nature …, 2017 - nature.com
Abstract ATP-phosphoribosyltransferase (ATP-PRT) is a hexameric enzyme in
conformational equilibrium between an open and seemingly active state and a closed and …
conformational equilibrium between an open and seemingly active state and a closed and …
Allosteric Inhibition of Acinetobacter baumannii ATP Phosphoribosyltransferase by Protein:Dipeptide and Protein:Protein Interactions
BJ Read, G Fisher, OLR Wissett… - ACS Infectious …, 2021 - ACS Publications
ATP phosphoribosyltransferase (ATPPRT) catalyzes the first step of histidine biosynthesis in
bacteria, namely, the condensation of ATP and 5-phospho-α-d-ribosyl-1-pyrophosphate …
bacteria, namely, the condensation of ATP and 5-phospho-α-d-ribosyl-1-pyrophosphate …
A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase
Adenosine triphosphate (ATP) phosphoribosyltransferase (ATP-PRT) catalyses the first
committed step of histidine biosynthesis in plants and microorganisms. Two forms of ATP …
committed step of histidine biosynthesis in plants and microorganisms. Two forms of ATP …
Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase
G Fisher, CM Thomson, R Stroek, CM Czekster… - Biochemistry, 2018 - ACS Publications
Short-form ATP phosphoribosyltransferase (ATPPRT) is a hetero-octameric allosteric
enzyme comprising four catalytic subunits (HisGS) and four regulatory subunits (HisZ) …
enzyme comprising four catalytic subunits (HisGS) and four regulatory subunits (HisZ) …
Transition state analysis of adenosine triphosphate phosphoribosyltransferase
Adenosine triphosphate phosphoribosyltransferase (ATP-PRT) catalyzes the first step in
histidine biosynthesis, a pathway essential to microorganisms and a validated target for …
histidine biosynthesis, a pathway essential to microorganisms and a validated target for …
Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase
MS Alphey, G Fisher, Y Ge, ER Gould… - ACS …, 2018 - ACS Publications
Allosteric modulation of catalysis is a common regulatory strategy of flux-controlling
biosynthetic enzymes. The enzyme ATP phosphoribosyltransferase (ATPPRT) catalyzes the …
biosynthetic enzymes. The enzyme ATP phosphoribosyltransferase (ATPPRT) catalyzes the …