Abstract Objectives Doxorubicin (Dox) belongs to the anthracycline drug classification and is
a widely administered chemotherapeutic. However, Dox use in therapy is limited by its …

Nanoparticles are fascinating and encouraging carriers for cancer treatment due to their
extraordinary properties and potential applications in targeted drug delivery, treatment, and …

Due to the cardiotoxicity of doxorubicin (DOX), its clinical application is limited. Lipid
peroxidation caused by excessive ferrous iron is believed to be a key molecular mechanism …

Background The protective effects of metformin (Met) against doxorubicin (Dox)-induced
cardiotoxicity via potential hypotheses of mechanisms of action with unknown reliability and …

Background A phase II clinical trial of metformin (MET) for the treatment of doxorubicin
(DOX)-induced cardiotoxicity (NCT02472353) failed. Objectives The aims of this study were …

Doxorubicin (Dox) is a widely used antitumor agent with dose-dependent and cumulative
cardiotoxic effects. Resveratrol (Res) is a natural non-flavonoid polyphenol that can …

Growing evidence indicates that silibinin (SLB), a main component extracted from Chinese
herb Silybum marianum, can effectively antagonize doxorubicin (DOX) induced myocardial …

Introduction Anthracycline chemotherapeutic agents are widely used in the treatment of
hematological and solid tumors, working principally through DNA intercalation and …

Introduction: Peri-operative chemotherapy is the backbone of treatment for patients with
osteosarcoma. Methotrexate, cisplatinum, doxorubicin and ifosfamide are the main drugs …

Dysregulation of calcium homeostasis is a major mechanism of doxorubicin (DOX)-induced
cardiotoxicity. Treatment with DOX causes activation of sarcoplasmic reticulum (SR) …