Antibiotic Resistance to Mycobacterium tuberculosis and Potential Use of Natural and Biological Products as Alternative Anti-Mycobacterial Agents
R Arrigoni, A Ballini, S Topi, L Bottalico, E Jirillo… - Antibiotics, 2022 - mdpi.com
Background: Tuberculosis (TB) is an infectious disease caused by the bacillus
Mycobacterium tuberculosis (Mtb). TB treatment is based on the administration of three …
Mycobacterium tuberculosis (Mtb). TB treatment is based on the administration of three …
The immunogenetics of tuberculosis (TB) susceptibility
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause
of death due to a single bacterial agent, with approximately 10.6 million people developing …
of death due to a single bacterial agent, with approximately 10.6 million people developing …
Phenotype Definition for “Resisters” to Mycobacterium tuberculosis Infection in the Literature—A Review and Recommendations
Tuberculosis (TB) remains a worldwide problem. Despite the high disease rate, not all who
are infected with Mycobacterium Tuberculosis (Mtb) develop disease. Interferon-γ (IFN-γ) …
are infected with Mycobacterium Tuberculosis (Mtb) develop disease. Interferon-γ (IFN-γ) …
Genetic epidemiology of resistance to M. tuberculosis Infection: importance of study design and recent findings
CM Stein - Genes & Immunity, 2023 - nature.com
Resistance to M. tuberculosis, often referred to as “RSTR” in the literature, is being
increasingly studied because of its potential relevance as a clinical outcome in vaccine …
increasingly studied because of its potential relevance as a clinical outcome in vaccine …
Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture
The heritability of susceptibility to tuberculosis (TB) disease has been well recognized. Over
100 genes have been studied as candidates for TB susceptibility, and several variants were …
100 genes have been studied as candidates for TB susceptibility, and several variants were …
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Background The role of IL-6 responses in human tuberculosis risk is unknown. IL-6
signalling inhibitors, such as tocilizumab, are thought to increase the risk of progression to …
signalling inhibitors, such as tocilizumab, are thought to increase the risk of progression to …
The mutational signatures of poor treatment outcomes on the drug-susceptible Mycobacterium tuberculosis genome
Drug resistance is a known risk factor for poor tuberculosis (TB) treatment outcomes, but the
contribution of other bacterial factors to poor outcomes in drug-susceptible TB is less well …
contribution of other bacterial factors to poor outcomes in drug-susceptible TB is less well …
Personalised medicine for tuberculosis and non-tuberculous mycobacterial pulmonary disease
K Kumar, OM Kon - Microorganisms, 2021 - mdpi.com
Personalised medicine, in which clinical management is individualised to the genotypic and
phenotypic data of patients, offers a promising means by which to enhance outcomes in the …
phenotypic data of patients, offers a promising means by which to enhance outcomes in the …
Immunological lessons from genome-wide association studies of infections
Highlights•The interindividual variability in response to infection is largely
unexplained.•Genome-wide technologies are powerful tools to investigate infections.•GWAS …
unexplained.•Genome-wide technologies are powerful tools to investigate infections.•GWAS …
[HTML][HTML] Altered IL-6 signalling and risk of tuberculosis disease: a meta-analysis and Mendelian randomisation study
IL-6 responses are ubiquitous in Mycobacterium tuberculosis (Mtb) infections, but their role
in determining human tuberculosis (TB) disease risk is unknown. We used single nucleotide …
in determining human tuberculosis (TB) disease risk is unknown. We used single nucleotide …