[HTML][HTML] Insight into extracellular vesicle-cell communication: from cell recognition to intracellular fate

L Ginini, S Billan, E Fridman, Z Gil - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …

[HTML][HTML] Microglia and astrocyte function and communication: what do we know in humans?

EF Garland, IJ Hartnell, D Boche - Frontiers in neuroscience, 2022 - frontiersin.org
Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons

Z Ruan, D Pathak, S Venkatesan Kalavai… - Brain, 2021 - academic.oup.com
Extracellular vesicles are highly transmissible and play critical roles in the propagation of tau
pathology, although the underlying mechanism remains elusive. Here, for the first time, we …

Plant exosomes as novel nanoplatforms for microRNA transfer stimulate neural differentiation of stem cells in vitro and in vivo

XH Xu, TJ Yuan, HA Dad, MY Shi, YY Huang… - Nano …, 2021 - ACS Publications
Differentiation of bone marrow derived mesenchymal stem cells (BMSCs) into functional
neural cells has been widely investigated for treating neural diseases. However, the limited …

ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids

Y You, Z Zhang, N Sultana, M Ericsson, YA Martens… - Science …, 2023 - science.org
Neuron-derived extracellular vesicles (NDEVs) are potential biomarkers of neurological
diseases although their reliable molecular target is not well established. Here, we …

Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain

Y You, S Muraoka, MP Jedrychowski… - Journal of …, 2022 - Wiley Online Library
In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules
and are consequently involved in disease progression. We have investigated the proteomic …

[HTML][HTML] Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges

S Dutta, S Hornung, HB Taha, G Bitan - Acta neuropathologica, 2023 - Springer
Extracellular vesicles (EVs), including exosomes, microvesicles, and oncosomes, are nano-
sized particles enclosed by a lipid bilayer. EVs are released by virtually all eukaryotic cells …

[HTML][HTML] Extracellular vesicles as signaling mediators and disease biomarkers across biological barriers

P Simeone, G Bologna, P Lanuti… - International journal of …, 2020 - mdpi.com
Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific
biological information and have progressively emerged as key regulators of organized …

The emerging role of exosomes in Alzheimer's disease

T Zhang, S Ma, J Lv, X Wang, HK Afewerky, H Li… - Ageing research …, 2021 - Elsevier
Abstract Alzheimer's disease (AD), manifested by memory loss and a decline in cognitive
functions, is the most prevalent neurodegenerative disease accounting for 60–80% of …

[HTML][HTML] The emerging role of neural cell-derived exosomes in intercellular communication in health and neurodegenerative diseases

L Huo, X Du, X Li, S Liu, Y Xu - Frontiers in Neuroscience, 2021 - frontiersin.org
Intercellular communication in the central nervous system (CNS) is essential for brain
growth, development, and homeostasis maintenance and, when dysfunctional, is involved in …