For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

The O2 J generated by this enzyme serves as the starting material for the production of a
vast assortment of reactive oxidants, including oxidized halogens, free radicals, and singlet …

Human and murine neutrophils differ with respect to representation in blood, receptors,
nuclear morphology, signaling pathways, granule proteins, NADPH oxidase regulation …

Proton channels exist in a wide variety of membrane proteins where they transport protons
rapidly and efficiently. Usually the proton pathway is formed mainly by water molecules …

The small G proteins of the Ras family act as bimodal relays in the transfer of intracellular
signals. This is a dynamic phenomenon involving a cascade of protein–protein interactions …

Neutrophils play an essential role in the body's innate defense against pathogens and are
one of the primary mediators of the inflammatory response. To defend the host, neutrophils …

In recent years, it has become clear that reactive oxygen species (ROS, which include
superoxide, hydrogen peroxide, and other metabolites) are produced in biological systems …

Pseudomonas aeruginosa is an opportunistic pathogen that forms biofilms on tissues and
other surfaces. We characterized the interaction of purified human neutrophils with P …

Rac1 is a member of the Ras superfamily of small guanosine triphosphatases (GTPases)
that act as molecular switches to control cytoskeletal rearrangements and cell growth …

Neutrophils play an essential role in host defense against microbial pathogens and in the
inflammatory reaction. Upon activation, neutrophils produce superoxide anion (O _2^-.) …