Members of the GroEL/HSP60 protein family have been studied for many years because of
their critical roles as ATP-dependent molecular chaperones, so it might come as a surprise …

Adaption of a single protein to perform multiple independent functions facilitates functional
plasticity of the proteome allowing a limited number of protein-coding genes to perform a …

A general principle of biology is the self‐assembly of proteins into functional complexes.
Characterizing their composition is, therefore, required for our understanding of cellular …

It is not often realized that the absolute protein specificity is an exception rather than a rule.
Two major kinds of protein multi-specificities are promiscuity and moonlighting. This review …

How do cells maintain relative proportions of protein complex components? Advances in
quantitative, genome-wide measurements have begun to shed light onto the roles of protein …

Moonlighting proteins are defined as proteins with two or more functions that are unrelated
and independent to each other, so that inactivation of one of them should not affect the …

A global protein interactome ensures the maintenance of regulatory, signaling and structural
processes in cells, but at the same time, aberrations in the repertoire of protein–protein …

Abstract MoonProt 2.0 (http://moonlightingproteins. org) is an updated, comprehensive and
open-access database storing expert-curated annotations for moonlighting proteins …

Abstract MoonProt 3.0 (http://moonlightingproteins. org) is an updated open-access
database storing expert-curated annotations for moonlighting proteins. Moonlighting …

Moonlighting proteins comprise a class of multifunctional proteins in which a single protein
performs multiple physiologically relevant biochemical or biophysical functions that are not …