Atherosclerotic cardiovascular disease results in> 19 million deaths annually, and coronary
heart disease accounts for the majority of this toll. Despite major advances in treatment of …

The paradigm of using nanoparticulate pharmaceutical carriers has been well established
over the past decade, both in pharmaceutical research and in the clinical setting. Drug …

Background—High-resolution visualization of atherosclerotic plaque morphology may be
essential for identifying coronary plaques that cause acute coronary events. Optical …

Acute myocardial infarction is a common disease with serious consequences in mortality,
morbidity, and cost to the society. Coronary atherosclerosis plays a pivotal part as the …

Background—In vivo detection of vulnerable plaques is presently limited by a lack of
diagnostic tools. Intravascular ultrasound elastography is a new technique based on …

Optical coherence tomography (OCT) is rapidly becoming the method of choice for
assessing arterial wall pathology in vivo. Atherosclerotic plaques can be diagnosed with …

Once plaques intrude into the lumen, the shear stress they are exposed to alters with
hitherto unknown consequences for plaque composition. We investigated the relationship …

Cardiovascular diseases are still the primary causes of mortality in the United States and in
Western Europe. Arterial thrombosis is triggered by a ruptured atherosclerotic plaque and …

The atomic force microscope (AFM) is emerging as a powerful tool in cell biology. Originally
developed for high‐resolution imaging purposes, the AFM also has unique capabilities as a …

Background—Plaque rupture with subsequent thrombosis is recognized as the underlying
pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus …