An integrated perspective for the diagnosis and therapy of neurodevelopmental disorders–From an engineering point of view

NM Hemed, NA Melosh - Advanced Drug Delivery Reviews, 2023 - Elsevier
Neurodevelopmental disorders (NDDs) are complex conditions with largely unknown
pathophysiology. While many NDD symptoms are familiar, the cause of these disorders …

Psychostimulants and social behaviors

V Cid-Jofré, T Bahamondes, A Zúñiga Correa… - Frontiers in …, 2024 - frontiersin.org
Mounting evidence from animal models and human studies indicates that psychostimulants
can significantly affect social behaviors. This is not surprising considering that the neural …

Selenium alleviates modafinil-induced neurobehavioral toxicity in rat via PI3K/Akt/mTOR/GSK3B signaling pathway and suppression of oxidative stress and apoptosis …

SA Shehata, E Kolieb, DA Ali, SA Maher… - … Science and Pollution …, 2024 - Springer
Nonmedical use of modafinil (MOD) led to increased rates of overdose toxicity, road
accidents, addiction, withdrawal, suicide, and mental illnesses. The current study aims to …

From molecular variations to behavioral adaptations: Unveiling adaptive epistasis in primate oxytocin system

P Vargas‐Pinilla, B S. Oliveira Fam… - American Journal of …, 2024 - Wiley Online Library
Objective Our primary objective was to investigate the variability of oxytocin (OT) and the
GAMEN binding motif within the LNPEP oxytocinase in primates. Materials and Methods We …

Modafinil Administration to Preadolescent Rat Impairs Non-Selective Attention, Frontal Cortex D2 Expression and Mesolimbic GABA Levels

V Cid-Jofré, M Moreno, R Sotomayor-Zárate… - International Journal of …, 2022 - mdpi.com
The misuse of psychostimulants is an increasing behavior among young people,
highlighting in some countries the abuse of modafinil (MOD) as a neuropotentiator …

Fast Scan Cyclic Voltammetry to Assess Dopamine Function: From Circuits to Behavior

PJ Clark, RA España - Dopaminergic System Function and Dysfunction …, 2022 - Springer
Electrochemical techniques have allowed investigators to measure analytes of interest for
decades. Of these techniques, fast scan cyclic voltammetry (FSCV) offers advantages that …

Playful pathfinders: elucidating the direct contribution of mPFC pathways to social play behaviour in rats

L Delwel - 2024 - studenttheses.uu.nl
Social play is thought to be fundamental for the proper development of social, motoric and
cognitive skills. Therefore, deficient social play, as reported in children with autism and …

Unravelling the Role of the Dopamine D1 Receptor in Anhedonia, Asociality, and Avolition

K Witt - 2023 - openaccess.wgtn.ac.nz
Despite major advances in neuroscience, there has been limited progress in improving
pharmacological treatment for neuropsychiatric disorders. Neuropsychiatric disorders are …

Targeting Hypocretin Receptor 1 to Normalize Nucleus Accumbens Dopamine Transmission and Block Incubation of Cocaine Seeking

PJ Clark - 2022 - search.proquest.com
Cocaine use disorder is a devastating condition for which there are no approved
pharmacotherapies. A robust body of work indicates that Nucleus Accumbens (NAc) …