The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin
domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent …

Traumatic brain injury (TBI) represents an important problem of global health. The damage
related to TBI is first due to the direct injury and then to a secondary phase in which …

Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and
individuals under 45 year age. A wide variety of cellular and molecular mechanisms have …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

Ischemic stroke (also called cerebral ischemia) is one of the leading causes of death and
severe disability worldwide. NLR inflammasomes play a crucial role in sensing cell damage …

Programmed cell death (PCD) is a fundamental biological process for maintaining cellular
equilibrium and regulating development, health, and disease across all living organisms …

Ion channels and transporters typically consist of biomolecules that play key roles in a large
variety of physiological and pathological processes. Traditional therapies include many ion …

Diabetes is one of the significant risk factors for ischemic stroke. Hyperglycemia exacerbates
the pathogenesis of stroke, leading to more extensive cerebral damage and, as a result, to …

Significance: Autophagy and apoptosis are two important cellular mechanisms behind brain
injuries, which are severe clinical situations with increasing incidences worldwide. To …

Stroke is a common disease in clinical practice, which seriously endangers people's
physical and mental health. The neurovascular unit (NVU) plays a key role in the occurrence …