Saponins as cytotoxic agents: An update (2010–2021). Part II—Triterpene saponins

I Podolak, K Grabowska, D Sobolewska… - Phytochemistry …, 2023 - Springer
Saponins make up an important group of natural glycosidic compounds which are
distinguished by triterpene or steroidal aglycone. Although widely distributed in terrestrial …

Natural compounds in sex hormone-dependent cancers: The role of triterpenes as therapeutic agents

C Şoica, M Voicu, R Ghiulai, C Dehelean… - Frontiers in …, 2021 - frontiersin.org
Sex hormone-dependent cancers currently contribute to the high number of cancer-related
deaths worldwide. The study and elucidation of the molecular mechanisms underlying the …

Medicinal plants used by 'root doctors', local traditional healers in Bié province, Angola

B Novotna, Z Polesny, MF Pinto-Basto… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance This study is one of the first post-civil war efforts to
document traditional botanical knowledge in Bié province, central Angola, in a first step to …

[HTML][HTML] PKI-587 enhances chemosensitivity of oxaliplatin in hepatocellular carcinoma through suppressing DNA damage repair pathway (NHEJ and HR) and PI3K …

Y Zhang, C Xie, A Li, X Liu, Y Xing, J Shen… - American journal of …, 2019 - ncbi.nlm.nih.gov
Oxaliplatin resistance limits its effectiveness in the treatment of hepatocellular carcinoma
(HCC). Abnormal activation of the PI3K/AKT/mTOR pathway has been associated with …

Circular RNA CDR1as exerts oncogenic properties partially through regulating MicroRNA 641 in cholangiocarcinoma

D Li, Z Tang, Z Gao, P Shen, Z Liu… - Molecular and Cellular …, 2020 - Taylor & Francis
It has been found that the circular RNA (circRNA) CDR1as is upregulated in
cholangiocarcinoma (CCA) tissues. In this study, we tried to explore the roles of CDR1as in …

Human papillomavirus associated cervical lesion: pathogenesis and therapeutic interventions

J Ye, L Zheng, Y He, X Qi - MedComm, 2023 - Wiley Online Library
Human papillomavirus (HPV) is the most prevalent sexually transmitted virus globally.
Persistent high‐risk HPV infection can result in cervical precancerous lesions and cervical …

The use of African medicinal plants in cancer management

G Gaobotse, S Venkataraman, PD Brown… - Frontiers in …, 2023 - frontiersin.org
Cancer is the third leading cause of premature death in sub-Saharan Africa. Cervical cancer
has the highest number of incidences in sub-Saharan Africa due to high HIV prevalence …

LINC02595 promotes tumor progression in colorectal cancer by inhibiting miR‐203b‐3p activity and facilitating BCL2L1 expression

Z Yang, Y An, N Wang, X Dong… - Journal of Cellular …, 2020 - Wiley Online Library
Colorectal cancer (CRC) is one of the most prevalent tumors worldwide. Recently, long
noncoding RNAs (lncRNAs) have been recognized as key regulators in postgenomic …

Medicinal plants for glioblastoma treatment

S Datta, R Luthra, N Bharadvaja - Anti-Cancer Agents in …, 2022 - ingentaconnect.com
Glioblastoma, an aggressive brain cancer, demonstrates the least life expectancy among all
brain cancers. Because of the regulation of diverse signaling pathways in cancers, the …

Structural diversity, natural sources, and pharmacological potential of plant-based saponins with special focus on anticancer activity: a review

M Rehan, Shafiullah, SA Mir - Medicinal chemistry research, 2020 - Springer
Saponins are a class of amphipathic glycosides prevalent in various plant species. They are
very important for human health and may be used in various drug formulations. Saponins …