The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Insulin-like growth factor 2 (IGF2) emerged as a critical mechanism of synaptic plasticity and
learning and memory. Deficits in IGF2 in the brain, serum, or cerebrospinal fluid (CSF) are …

Background Major depressive disorder is a widespread mood disorder. One of the most
debilitating symptoms patients often experience is cognitive impairment. Recent findings …

Neurodegenerative disorders are spreading worldwide and are one of the greatest threats to
public health. There is currently no adequate therapy for these disorders, and therefore there …

The etiology of autism spectrum disorder (ASD) remains unknown, but gene-environment
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …

Investigations of memory mechanisms have been, thus far, neuron centric, despite the brain
comprising diverse cell types. Using rats and mice, we assessed the cell-type-specific …

Fragile X syndrome is caused by FMR1 gene silencing and loss of the encoded fragile X
mental retardation protein (FMRP), which binds to mRNA and regulates translation. Studies …

Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there
are no effective treatments or cures. Herein, we report on a tetrahydroquinoline-based …

A number of studies performed on rodents suggest that insulin-like growth factor 2 (IGF-2) or
its analogs may possibly be used for treating some conditions like Alzheimer's disease …

Insulin-like growth factor 2 (IGF2) is abundantly expressed in the central nervous system
(CNS). Recent evidence highlights the role of IGF2 in the brain, sustained by data showing …