Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
The nucleus accumbens: a comprehensive review
S Salgado, MG Kaplitt - Stereotactic and functional neurosurgery, 2015 - karger.com
There is increasing interest among functional neurosurgeons in the potential for novel
therapies to impact upon diseases beyond movement disorders and pain. A target of …
therapies to impact upon diseases beyond movement disorders and pain. A target of …
The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors
DH Root, RI Melendez, L Zaborszky, TC Napier - Progress in neurobiology, 2015 - Elsevier
The ventral pallidum (VP) plays a critical role in the processing and execution of motivated
behaviors. Yet this brain region is often overlooked in published discussions of the …
behaviors. Yet this brain region is often overlooked in published discussions of the …
Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence
High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
Neurobiology of the incubation of drug craving
CL Pickens, M Airavaara, F Theberge, S Fanous… - Trends in …, 2011 - cell.com
It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively
increases over the first several weeks of abstinence and remains high for extended periods …
increases over the first several weeks of abstinence and remains high for extended periods …
The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
Background and rationale Results from many clinical studies suggest that drug relapse and
craving are often provoked by acute exposure to the self-administered drug or related drugs …
craving are often provoked by acute exposure to the self-administered drug or related drugs …
Opiate versus psychostimulant addiction: the differences do matter
The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
Relapse to cocaine use after prolonged abstinence is an important clinical problem. This
relapse is often induced by exposure to cues associated with cocaine use. To account for …
relapse is often induced by exposure to cues associated with cocaine use. To account for …
Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats
The rat prelimbic prefrontal cortex and nucleus accumbens core are critical for initiating
cocaine seeking. In contrast, the neural circuitry responsible for inhibiting cocaine seeking …
cocaine seeking. In contrast, the neural circuitry responsible for inhibiting cocaine seeking …