Mucosal surfaces—such as the lining of the gut or the reproductive tract—are the main point
of entry for viruses into the body. As such, almost all viruses interact with epithelial cells, and …

The causative agent of foot-and-mouth disease was first identified as a virus by Loeffler and
Frosch (1897)(see Brown, this volume), but visualisation of its general morphology was not …

Infection by field strains of Foot-and-mouth disease virus (FMDV) is initiated by binding to
certain species of arginine-glycine-aspartic acid (RGD)-dependent integrin including αvβ3 …

Foot-and-mouth disease virus (FMDV) RNA is infectious. After delivery of the RNA (about 8.3
kb) into the cytoplasm of a cell, the RNA must initially be translated to produce the viral …

Integrins are a family of heterodimeric cell surface receptors, which are expressed on most
cells where they mediate cell‐cell and cell‐extracellular matrix (ECM) interactions. The αvβ6 …

Field isolates of foot-and-mouth disease virus (FMDV) have been shown to use three αv
integrins, αvβ1, αvβ3, and αvβ6, as cellular receptors. Binding to the integrin is mediated by …

We have shown that foot-and-mouth disease virus (FMDV) infection mediated by the integrin
αvβ6 takes place through clathrin-dependent endocytosis but not caveolae or other …

Foot-and-mouth disease virus (FMDV) can use a number of integrins as receptors to initiate
infection. Attachment to the integrin is mediated by a highly conserved arginine-glycine …

ABSTRACT Coxsackievirus A9 (CAV9), a member of the Enterovirus genus of
Picornaviridae, is a common human pathogen and is one of a significant number of viruses …

Structural studies of foot-and-mouth disease virus (FMDV) have largely focused on the
mature viral particle, providing atomic resolution images of the spherical protein capsid for a …