Background Humanin (HN) is an endogenous peptide factor and known as a member of
mitochondrial-derived peptides. We first found the gene encoding this novel 24-residue …

Simple Summary Humanin was discovered in 2001 as a biological factor with
neuroprotective activity. This review article presents research results that have supported the …

The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-
cell lymphoma 2 (BCL-2) protein family. BCL-2–associated X apoptosis regulator (BAX) …

Alzheimer's disease is a neurodegenerative disease induced by multiple interconnected
mechanisms. Peptide drug candidates with multi-modal efficacy generated from fusion …

Humanin comprising 24 amino acid residues is a bioactive peptide that has been isolated
from the brain tissue of patients with Alzheimer's disease. Humanin reportedly suppressed …

Alzheimer's disease (AD) is a complex disease, involving multiple factors such as the
production of aggregation-prone amyloid β (Aβ) peptides, the formation of fibrillarly tangles …

The aggregation of soluble amyloid‐beta (Aβ) peptide into oligomers/fibrils is one of the key
pathological features in Alzheimer's disease (AD). The Aβ aggregates are considered to …

Humanin is a short endogenous peptide, which can provide protection from cell death
through its association with various receptors, including the pro‐apoptotic Bcl‐2 family …

A single mutation has resulted in large differences in neuroprotective activity of a 24 amino
acid Humanin (HN). A mutation of Ser7Ala (S7A-HN) resulted in loss of activity, while a …

Humanin (HN) is a recently identified neuroprotective peptide able to inhibit neurotoxicity
induced by various insults which can be related to Alzheimer disease (AD) as well as to cell …