Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Neanderthal brains were similar in size to those of modern humans. We sought to
investigate potential differences in neurogenesis during neocortex development. Modern …

The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

To defense harmful stimuli or maintain the immune homeostasis, the body produces and
recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

Microglia are specialized brain-resident macrophages that arise from primitive macrophages
colonizing the embryonic brain. Microglia contribute to multiple aspects of brain …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …