The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

In many circumstances alternative courses of action and thoughts have to be inhibited to
allow the emergence of goal-directed behavior. However, this has not been the accepted …

In 2008, the National Institute of Mental Health (NIMH) included in its new Strategic Plan the
following aim:“Develop, for research purposes, new ways of classifying mental disorders …

Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The
revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and …

Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

Brain dopamine (DA) has long been implicated in cognitive control processes, including
working memory. However, the precise role of DA in cognition is not well-understood, partly …

The prefrontal cortex (PFC)—the most evolved brain region—subserves our highest-order
cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental …

Neuroscientists have long observed that brain activity is naturally variable from moment-to-
moment, but neuroimaging research has largely ignored the potential importance of this …

Research into the heterogeneous nature of cognitive impairment documented in patients
with Parkinson's disease (PD) has focused on disentangling deficits that vary between …

Through neuromodulatory influences over fronto-striato-cerebellar circuits, dopamine and
noradrenaline play important roles in high-level executive functions often reported to be …