Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
Cellular senescence: all roads lead to mitochondria
Senescence is a multi‐functional cell fate, characterized by an irreversible cell‐cycle arrest
and a pro‐inflammatory phenotype, commonly known as the senescence‐associated …
and a pro‐inflammatory phenotype, commonly known as the senescence‐associated …
SIRT6 protects smooth muscle cells from senescence and reduces atherosclerosis
MOJ Grootaert, A Finigan, NL Figg, AK Uryga… - Circulation …, 2021 - Am Heart Assoc
Rationale: Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and
features of plaque instability, in part, through lipid-mediated oxidative DNA damage and …
features of plaque instability, in part, through lipid-mediated oxidative DNA damage and …
Periodontal microorganisms and Alzheimer disease–A causative relationship?
G Jungbauer, A Stähli, X Zhu… - Periodontology …, 2022 - Wiley Online Library
In the initiation or exacerbation of Alzheimer disease, the dissemination of oral
microorganisms into the brain tissue or the low‐level systemic inflammation have been …
microorganisms into the brain tissue or the low‐level systemic inflammation have been …
Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance
Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …
and can accelerate diabetes-related microvascular and macrovascular complications by …
Microbiome and human aging: probiotic and prebiotic potentials in longevity, skin health and cellular senescence
The role of the microbiome in human aging is important: the microbiome directly impacts
aging through the gastrointestinal system. However, the microbial impact on skin has yet to …
aging through the gastrointestinal system. However, the microbial impact on skin has yet to …
SARS-CoV-2 mediated endothelial dysfunction: the potential role of chronic oxidative stress
Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …
Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized
by a high mortality of elderly men with age-related comorbidities. In most of these patients …
by a high mortality of elderly men with age-related comorbidities. In most of these patients …
Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: new insights into the mechanisms and therapeutic potentials
Thrombolytic therapy and revascularization strategies create a complete recanalization of
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …
The role of osteoclast energy metabolism in the occurrence and development of osteoporosis
W Da, L Tao, Y Zhu - Frontiers in endocrinology, 2021 - frontiersin.org
In recent decades, the mechanism underlying bone metabolic disorders based on energy
metabolism has been heavily researched. Bone resorption by osteoclasts plays an important …
metabolism has been heavily researched. Bone resorption by osteoclasts plays an important …