Abstract Uridine 5′-diphosphoglucose (UDP-G) as a preferential agonist, but also other
UDP-sugars, such as UDP galactose, function as extracellular signaling molecules under …

Abstract Prof. Geoffrey Burnstock originated the concept of purinergic signaling. He
demonstrated the interactions and biological roles of ionotropic P2X and metabotropic P2Y …

Renal fibrosis is a common consequence of various progressive nephropathies, including
obstructive nephropathy, and ultimately leads to kidney failure. Infiltration of inflammatory …

Acute ischemic stroke has become the major cause of mortality and disability worldwide.
Following ischemic stroke, the reperfusion injury is mainly mediated by the burst of reactive …

Purinergic signaling plays a causal role in the pathogenesis of inflammatory bowel disease.
Among purinoceptors, only P2Y14R is positively correlated with inflammatory score in …

The β 2 adrenergic receptor agonist, formoterol, is an inducer of mitochondrial biogenesis
and restorer of mitochondrial and kidney function in acute and chronic models of kidney …

P2Y14 receptor (P2Y14R) is activated by extracellular UDP-glucose, a damage-associated
molecular pattern that promotes inflammation in the kidney, lung, fat tissue, and elsewhere …

Trigeminal nerve injury is a common complication of various dental and oral procedures,
which could induce trigeminal neuropathic pain but lack effective treatments. P2 purinergic …

Background Ligusticum striatum DC. is traditionally used to treat ischemic diseases because
of its potent effect against blood stasis and thrombosis, including various cardiovascular …

Airway eosinophilia is a hallmark of allergic asthma and is associated with mucus
production, airway hyperresponsiveness, and shortness of breath. Although glucocorticoids …