Low molecular weight synthetic peptides have been demonstrated to be effective catalysts
for an increasingly wide array of asymmetric transformations. In many cases, these peptide …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Non-natural folded polymers (foldamers) display considerable versatility, and the design of
such molecules is of great current interest. In this respect, peptidic foldamers are perhaps …

Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides
that fold into well-defined three-dimensional structures. They offer the chemical biologist a …

The origins of our nearly ten‐year research program of chemical and biological
investigations into peptides based on homologated proteinogenic amino acids are …

The functions performed by proteins and nucleic acids provide the foundation for life.
Chemists have recently begun to ask whether it is possible to design synthetic oligomers …

The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

Host-defense peptides inhibit bacterial growth but manifest relatively little toxicity toward
eukaryotic cells. Many host-defense peptides adopt α-helical conformations in which …

The function of a protein generally depends on adoption of a specific folding pattern, which
in turn is determined by the side chain sequence along the polypeptide backbone. Here we …

We describe our first effort to design antimicrobial α/β-peptides based upon their helical
folding behavior. α/β-Peptide 3 (above), designed as a scrambled negative control …