Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …

The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …

Abstract Malignant Pleural Mesothelioma (MPM) is typically diagnosed 20–50 years after
exposure to asbestos and evolves along an unknown evolutionary trajectory. To elucidate …

Background Malignant pleural and peritoneal mesotheliomas are rare malignancies with
unacceptable poor prognoses and limited treatment options. The genomic landscape is …

Diffuse pleural mesothelioma (DPM) is a lethal cancer with a poor prognosis and limited
treatment options. The Hippo signaling pathway genes, such as NF2 and LATS1/2, are …

The NF2 tumor suppressor gene is a frequent somatically mutated gene in mesothelioma,
with 30%–40% mesotheliomas showing NF2 inactivation. NF2 encodes merlin, a member of …

Objective: The aim of this review is addressing the mechanisms of asbestos carcinogenesis,
including chronic inflammation and autophagy-mediated cell survival, and propose potential …

Canine malignant mesothelioma (cMM) is a rare and drug-resistant malignant tumor. Due to
few patients and experimental models, there have not been enough studies to demonstrate …

Mesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive
fibrotic response. The latter is in large part mediated by cancer-associated fibroblasts which …

Background More than half of mesothelioma tumours show alterations in the tumour
suppressor gene BAP1. BAP1-deficient mesothelioma is shown to be sensitive to EZH2 …