Tertiary lymphoid structures in the era of cancer immunotherapy

C Sautès-Fridman, F Petitprez, J Calderaro… - Nature Reviews …, 2019 - nature.com
Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-
lymphoid tissues at sites of chronic inflammation including tumours. Key common …

Tertiary lymphoid structures in cancer and beyond

MC Dieu-Nosjean, J Goc, NA Giraldo… - Trends in …, 2014 - cell.com
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed,
infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph …

[HTML][HTML] Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis

S Jamaly, M Rakaee, R Abdi, GC Tsokos… - Autoimmunity reviews, 2021 - Elsevier
Kidney involvement confers significant morbidity and mortality in patients with systemic
lupus erythematosus (SLE). The pathogenesis of lupus nephritis (LN) involves diverse …

Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure

Z Lin, L Huang, SL Li, J Gu, X Cui, Y Zhou - Scientific reports, 2020 - nature.com
How the genomic landscape of a tumor shapes the formation of tertiary lymphoid structure
(TLS) and how might TLS alter the clinical outcome or response to immunotherapy had not …

Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances

L Zhao, S Jin, S Wang, Z Zhang, X Wang… - … and Targeted Therapy, 2024 - nature.com
Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

Ectopic lymphoid follicles: inducible centres for generating antigen‐specific immune responses within tissues

GW Jones, SA Jones - Immunology, 2016 - Wiley Online Library
Lymphoid neogenesis is traditionally viewed as a pre‐programmed process that promotes
the formation of lymphoid organs during development. Here, the spatial organization of T …

Complexities in the relationship between infection and autoimmunity

R Root-Bernstein, DL Fairweather - Current allergy and asthma reports, 2014 - Springer
The possible role of infections in driving autoimmune disease (AD) has long been debated.
Many theories have emerged including release of hidden antigens, epitope spread, anti …

[HTML][HTML] Epstein–Barr virus-acquired immunodeficiency in myalgic encephalomyelitis—Is it present in long COVID?

M Ruiz-Pablos, B Paiva, A Zabaleta - Journal of Translational Medicine, 2023 - Springer
Both myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) and long COVID
(LC) are characterized by similar immunological alterations, persistence of chronic viral …

The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit

Y Hou, S Qiao, M Li, X Han, X Wei, Y Pang… - Frontiers in …, 2023 - frontiersin.org
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic
lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as …

Hypocortisolemic ASIA: a vaccine-and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis

M Ruiz-Pablos, B Paiva, A Zabaleta - Frontiers in Immunology, 2024 - frontiersin.org
Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), long COVID (LC) and
post-COVID-19 vaccine syndrome show similarities in their pathophysiology and clinical …