The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Parkinson's disease (PD) is the second most common neurodegenerative disease. PD
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …

Chronic neuroinflammation is a common feature of the ageing brain and some
neurodegenerative disorders. However, the molecular and cellular mechanisms underlying …

The Ca2+-binding protein of the EF-hand type, S100B, exerts both intracellular and
extracellular functions. Recent studies have provided more detailed information concerning …

Astrocytes contribute to chronic neuroinflammation in a variety of neurodegenerative
diseases, including Parkinson's disease (PD), the most common movement disorder …

Whilst astrocytes in culture invariably respond to dopamine with cytosolic Ca2+ rises, the
dopamine sensitivity of astroglia in situ and its physiological roles remain unknown. To …

Already in the 1960s the architecture and pharmacology of the brainstem dopamine (DA)
and noradrenaline (NA) neurons with formation of vast numbers of DA and NA terminal …

Perinatal asphyxia occurs still with great incidence whenever delivery is prolonged, despite
improvements in perinatal care. After asphyxia, infants can suffer from short-to long-term …

Astrocyte activation is associated with progressive inflammatory demyelination in multiple
sclerosis (MS). The molecular mechanisms underlying astrocyte activation remain …

Astrocytes provide neuroprotective effects against degeneration of dopaminergic (DA)
neurons and play a fundamental role in DA differentiation of neural stem cells. Here we …