The prefrontal cortex and obesity: a health neuroscience perspective

CJ Lowe, AC Reichelt, PA Hall - Trends in cognitive sciences, 2019 - cell.com
In the modern obesogenic environment, limiting calorie-dense food consumption is partially
dependent on the capacity of individuals to override visceral reactions to hyperpalatable and …

Mechanisms of weight regain.

L Busetto, S Bettini, J Makaronidis, CA Roberts… - European journal of …, 2021 - Elsevier
Weight regain following weight loss is frequent problem that people with obesity face. This
weight recidivism is often attributed to the lack of compliance with appropriate food habits …

Partial leptin reduction as an insulin sensitization and weight loss strategy

S Zhao, YI Zhu, RD Schultz, N Li, Z He, Z Zhang… - Cell metabolism, 2019 - cell.com
The physiological role of leptin is thought to be a driving force to reduce food intake and
increase energy expenditure. However, leptin therapies in the clinic have failed to effectively …

Leptin: less is more

S Zhao, CM Kusminski, JK Elmquist, PE Scherer - Diabetes, 2020 - Am Diabetes Assoc
The successful use of leptin for the treatment of individuals with lipodystrophy and leptin
deficiency is well established. However, pharmacological approaches of leptin therapy for …

Brain–body communication in metabolic control

A Furlan, P Petrus - Trends in Endocrinology & Metabolism, 2023 - cell.com
A thorough understanding of the mechanisms controlling energy homeostasis is needed to
prevent and treat metabolic morbidities. While the contribution of organs such as the liver …

Inhibitory control as a potential treatment target for obesity

MT De Klerk, PAM Smeets, SE La Fleur - Nutritional neuroscience, 2023 - Taylor & Francis
Objectives: Strong reward responsiveness to food and insufficient inhibitory control are
thought to be implicated in the development and maintenance of obesity. This narrative …

[HTML][HTML] Diminished prefrontal cortex activation in patients with binge eating disorder associates with trait impulsivity and improves after impulsivity-focused treatment …

R Veit, K Schag, E Schopf, M Borutta, J Kreutzer… - NeuroImage: Clinical, 2021 - Elsevier
Background Behavioral and cognitive control are vital for healthy eating behavior. Patients
with binge eating disorder (BED) suffer under recurrent binge eating episodes accompanied …

Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity

D Pretz, C Le Foll, MZ Rizwan, TA Lutz… - The FASEB …, 2021 - Wiley Online Library
Obesity has emerged as a major risk factor for insulin resistance leading to the development
of type 2 diabetes (T2D). The condition is characterized by high circulating levels of the …

Randomized controlled trial for time-restricted eating in overweight and obese young adults

L Zhang, Z Liu, J Wang, R Li, J Ren, X Gao, S Lv… - IScience, 2022 - cell.com
Time-restricted eating (TRE) is known to improve metabolic health, whereas very few studies
have compared the effects of early and late TRE (eTRE and lTRE) on metabolic health …

Is obesity related to enhanced neural reactivity to visual food cues? A review and meta-analysis

F Morys, I García-García… - Social cognitive and …, 2023 - academic.oup.com
Theoretical work suggests that obesity is related to enhanced incentive salience of food
cues. However, evidence from both behavioral and neuroimaging studies on the topic is …